Evidence-based knowledge about fibromyalgia — grounded in peer-reviewed research, written in plain language.
A Danish register study found no higher risk of complications after bariatric surgery in people with fibromyalgia. Quality-of-life gains after one year were smaller, and the group was small.
Read articleStart with the basics. Understanding what fibromyalgia is — and what it isn't — is the foundation for every other decision you'll make about your health.
In 317 teens with fibromyalgia, only a drop in fear of movement still predicted better daily functioning after one year. Pain catastrophising mattered only in the short term.
Read moreA Brazilian analysis of a 56-woman trial found hyperbaric oxygen met the local cost-effectiveness threshold. It costs more than standard care, and the evidence is still limited.
Read moreIn a Greek trial, three live online Pilates sessions a week lowered the impact of fibromyalgia more than usual care. Attendance was high and nobody reported side effects.
Read moreResearchers found three stable subgroups among 4,172 people with fibromyalgia. Mood and life circumstances separated the groups better than pain or fatigue.
Read moreThe largest comparison of fibromyalgia drugs to date found small benefits at best. Some drugs help with sleep or overall wellbeing, but none clearly reduced average pain.
Read moreIn UK Biobank, 72.6% of people who met the fibromyalgia criteria had no diagnosis. Men, older adults and people with milder symptoms were most often missed.
Read moreThe first trial to lower IgG antibodies in fibromyalgia cut them by 62% and improved overall impact scores — but missed its pain endpoint. An honest, important result.
Read moreNIH-funded researchers combined infrared spectroscopy with metabolomics and distinguished fibromyalgia from rheumatoid arthritis with an AUC of 0.84 — proof of concept, not a test you can order.
Read moreCarnegie Mellon and Pitt tested pulsed transcranial electrical stimulation in nine patients. It was tolerable and engaged pain circuits — but this is a feasibility pilot, not evidence it works.
Read moreA study of 188 women found partly distinct DNA methylation patterns: one axis specific to ME/CFS, another shared across both conditions and scaling with symptom burden.
Read moreThe largest and longest ketamine dataset in fibromyalgia so far: 92 patients, up to two years of follow-up. One in three kept more than 50% pain relief — but there was no control group.
Read moreA landmark study of 2.5 million people identifies 26 genetic risk regions and shows fibromyalgia is primarily a central nervous system disorder — not a psychological one.
Read moreA meta-analysis of 1,605 patients finds significantly elevated hsCRP, adding evidence that low-grade inflammation plays a real role for some patients with fibromyalgia.
Read moreThe INNOVA study, the first long-term placebo-controlled trial of low-dose naltrexone, found no meaningful benefit over placebo — an honest result worth knowing before trying it off-label.
Read moreUniversity of Utah validates the first reliable fibromyalgia animal model and identifies metformin and green light therapy as promising treatments now entering clinical trials.
Read moreA landmark JAMA study of 384 patients shows TENS combined with physical therapy reduces movement-evoked pain and fatigue as effectively as FDA-approved medications — new 180-day data show the benefit holds up.
Read moreAxsome Therapeutics begins the FORWARD Phase 3 trial for esreboxetine, a selective norepinephrine reuptake inhibitor — the most advanced new drug candidate for fibromyalgia currently in the pipeline.
Read moreNon-invasive neuromodulation shows promise in reducing fibromyalgia pain by balancing the nervous system.
Read moreNew research reveals an imbalance between Glutamate and GABA in the brain as a primary cause of fibromyalgia pain.
Read moreFirst new drug for fibromyalgia in 15 years. FDA approved (US) and currently being monitored in the Netherlands (Horizonscan).
Read moreNew international guidelines translated for patients, emphasizing multimodal care.
Read moreEU experts reframing fibromyalgia as a biological "volume" problem of the nervous system.
Read moreEmerging evidence of brain inflammation and potential autoimmune markers in fibromyalgia.
Read moreUnderstanding the condition, its symptoms, and why your pain is real.
Read moreWhy movement matters, what types help, and how to start safely.
Read moreWhy sleep matters in fibromyalgia and evidence-based strategies to improve it.
Read moreAn overview of pharmacological and non-pharmacological options.
Read moreWhat triggers flares, how to manage them, and when to seek help.
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